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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제37권 제4호
- 발행연도
- 2020.1
- 수록면
- 269 - 276 (8page)
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Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary fibrosis (IPF) is a common form of progressive and chronic interstitial lung disease of unknown etiology. Pathophysiologically, the parenchyma of the lung alveoli, interstitium, and capillary endothelium becomes scarred and stiff, which makes breathing difficult because the lungs have to work harder to transfer oxygen and carbon dioxide between the alveolar space and bloodstream. The transforming growth factor beta (TGF-?) signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis and scarring of the lung tissue. Recent clinical trials focused on the development of pharmacological agents that either directly or indirectly target kinases for the treatment of IPF. Therefore, to develop therapeutic targets for pulmonary fibrosis, it is essential to understand the key factors involved in the pathogenesis of pulmonary fibrosis and the underlying signaling pathway. The objective of this review is to discuss the role of kinase signaling cascades in the regulation of either TGF-?-dependent or other signaling pathways, including Rho-associated coiled-coil kinase, c-jun N-terminal kinase, extracellular signal-regulated kinase 5, and p90 ribosomal S6 kinase pathways, and potential therapeutic targets in IPF.
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참고문헌 (84)
참고문헌 신청
Bonnans C / 2014 / Remodelling the extracellular matrix in development and disease / Nat Rev Mol Cell Biol 15:786~801
Iredale JP / 2013 / Extracellular matrix degradation in liver fibrosis : biochemistry and regulation / Biochim Biophys Acta 1832:876~883
Borthwick LA / 2013 / Cytokine mediated tissue fibrosis / Biochim Biophys Acta 1832:1049~1060
Liu RM / 2010 / Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis / Free Radic Biol Med 48:1~15
Rockey DC / 2015 / Fibrosis : a common pathway to organ injury and failure / N Engl J Med 372:1138~1149
Iredale JP / 2013 / Extracellular matrix degradation in liver fibrosis : biochemistry and regulation / Biochim Biophys Acta 1832:876~883
Borthwick LA / 2013 / Cytokine mediated tissue fibrosis / Biochim Biophys Acta 1832:1049~1060
Liu RM / 2010 / Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis / Free Radic Biol Med 48:1~15
Rockey DC / 2015 / Fibrosis : a common pathway to organ injury and failure / N Engl J Med 372:1138~1149
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