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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 13 (13page)
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Background: Pulmonary hypertension (PH) is common in patients with idiopathic pulmonary fibrosis (IPF) and is associated with poor outcomes. This study was performed to determine the clinical efficacy of PH-specific therapeutic agents for IPF patients. Methods: We performed a systematic review and meta-analysis using MEDLINE, EMBASE, and the Cochrane Central Register. We searched randomized controlled trials (RCTs) without language restriction until November 2018. The primary outcome was all-cause mortality to end of study. Results: We analyzed 10 RCTs involving 2,124 patients, 1,274 of whom received PH-specific agents. In pooled estimates, the use of PH-specific agents was not significantly associated with reduced all-cause mortality to end of study compared with controls (hazard ratio, 0.99; 95% confidence interval [CI], 0.92, 1.06; P = 0.71; I 2 = 30%). When we performed subgroup analyses according to the type of PH-specific agent, sample size, age, forced vital capacity, diffusion lung capacity, and the extent of honeycombing, PH-specific agents also showed no significant association with a reduction in all-cause mortality. A small but significant improvement in quality of life, measured using the St. George Respiratory Questionnaire total score, was found in the PH-specific agent group (mean difference, −3.16 points; 95% CI, −5.34, −0.97; P = 0.005; I 2 = 0%). We found no significant changes from baseline in lung function, dyspnea, or exercise capacity. Serious adverse events were similar between the two groups. Conclusion: Although PH-specific agents provided small health-related quality-of-life benefits, our meta-analysis provides insufficient evidence to support their use in IPF patients.
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참고문헌 (43)
참고문헌 신청
Raghu G / 2018 / Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline / Am J Respir Crit Care Med 198(5):e44~e68
Carlos WG / 2016 / Treatment of idiopathic pulmonary fibrosis / Ann Am Thorac Soc 13(1):115~117
Raghu G / 2015 / An official ATS/ERS/JRS/ALAT clinical practice guideline : treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline / Am J Respir Crit Care Med 192(2):e3~e19
Lettieri CJ / 2006 / Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis / Chest 129(3):746~752
Nadrous HF / 2005 / Pulmonary hypertension in patients with idiopathic pulmonary fibrosis / Chest 128(4):2393~2399
Carlos WG / 2016 / Treatment of idiopathic pulmonary fibrosis / Ann Am Thorac Soc 13(1):115~117
Raghu G / 2015 / An official ATS/ERS/JRS/ALAT clinical practice guideline : treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline / Am J Respir Crit Care Med 192(2):e3~e19
Lettieri CJ / 2006 / Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis / Chest 129(3):746~752
Nadrous HF / 2005 / Pulmonary hypertension in patients with idiopathic pulmonary fibrosis / Chest 128(4):2393~2399
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