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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 19 - 25 (7page)
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Vascular endothelial growth factor (VEGF) is an important regulator of neovascularization. Hypoxia inducible nitric oxide (NO) enhanced the expression of VEGF and thymosin beta-4 ($T{\beta}4$), actin sequestering protein. Here, we investigated whether NO-mediated VEGF expression could be regulated by $T{\beta}4$ expression in HeLa cervical cancer cells. Hypoxia inducible NO production and VEGF expression were reduced by small interference (si) RNA of $T{\beta}4$. Hypoxia response element (HRE)-luciferase activity and VEGF expression were increased by the treatment with N-(${\beta}$-D-Glucopyranosyl)-N2-acetyl-S-nitroso-D, L-penicillaminamide (SNAP-1), to generate NO, which was inhibited by the inhibition of $T{\beta}4$ expression with $T{\beta}4$-siRNA. In hypoxic condition, HRE-luciferase activity and VEGF expression were inhibited by the treatment with $N^G$-monomethyl-L-arginine (L-NMMA), an inhibitor to nitric oxide synthase (NOS), which is accompanied with a decrease in $T{\beta}4$ expression. VEGF expression inhibited by L-NMMA treatment was restored by the transfection with pCMV-$T{\beta}4$ plasmids for $T{\beta}4$ overexpression. Taken together, these results suggest that $T{\beta}4$ could be a regulator for the expression of VEGF via the maintenance of NOS activity.
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참고문헌 (43)
참고문헌 신청
Brakebusch, C. / 2005 / beta 1 integrin function in vivo:adhesion, migration and more / Cancer Metastasis Rev 24:403~411
Chamorro-Jorganes, A. / 2011 / Fibronectin upregulates cGMP-dependent protein kinase type Ibeta through C/EBP transcription factor activation in contractile cells / Am. J. Physiol. Cell Physiol 300:C683~C691
Chartrain, N. A. / 1994 / Molecular-cloning, structure, and chromosomal localization of the human inducible nitric-oxide synthase gene / J. Biol. Chem 269:6765~6772
Cho, W. K. / 2004 / Oncolytic effects of adenovirus mutant capable of replicating in hypoxic and normoxic regions of solid tumor / Mol. Ther 10:938~949
Curran, J. / 2014 / Nitric oxidedependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation / PLoS ONE 9:e87495
Chamorro-Jorganes, A. / 2011 / Fibronectin upregulates cGMP-dependent protein kinase type Ibeta through C/EBP transcription factor activation in contractile cells / Am. J. Physiol. Cell Physiol 300:C683~C691
Chartrain, N. A. / 1994 / Molecular-cloning, structure, and chromosomal localization of the human inducible nitric-oxide synthase gene / J. Biol. Chem 269:6765~6772
Cho, W. K. / 2004 / Oncolytic effects of adenovirus mutant capable of replicating in hypoxic and normoxic regions of solid tumor / Mol. Ther 10:938~949
Curran, J. / 2014 / Nitric oxidedependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation / PLoS ONE 9:e87495
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