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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 361 - 369 (9page)
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Background Cancer-induced bone pain (CIBP) is the pain caused by bone metastasis from malignant tumors, and the largest source of pain for cancer patients. miR-300 is an important miRNA in cancer. It has been shown that miR-300 regulates tumorigenesis of various tumors. Purpose This study aims to investigate the role of miR-300 in CIBP and its underlying molecular mechanisms in vitro and in vivo. Methods We constructed CIBP model in rats and investigated the mechanism through which miR-300 affects CIBP. We first examined expression level of miR-300 in CIBP rats and then tested the effect of its overexpression. Next, we identified the target of miR-300 using TargetScan analysis and double luciferase assay. Finally, we studied genetic interactions between miR-300 and its target and their roles in CIBP. Results We found that miR-300 was downregulated in CIBP rats. Overexpression of miR-300 significantly attenuated cancerinduced neuropathic pain (p < 0.01). Furthermore, TargetScan analysis and double luciferase assay show High Mobility Group Box 1 (HMGB1) is a target of miR-300. Notably, HMGB1 is overexpressed in CIBP rats, while up-regulation of miR300 significantly suppresses expression of HMGB1 (p < 0.01). Moreover, knockdown of HMGB1 by siRNA significantly relieves cancer-induced neuropathic pain in rats (p < 0.01). On the other hand, HMGB1 overexpression partially blocked the effect of miR-300 on cancer-induced nerve pain. Conclusion miR-300 relieves cancer-induced neuropathic pain by inhibiting HMGB1 expression. These results may be beneficial for the treatment of CIBP in clinical practice.
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참고문헌 (34)
참고문헌 신청
Bernardino L / 2005 / Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPAinduced excitotoxicity in mouse organotypic hippocampal slice cultures / J Neurosci 25(29):6734~6744
Chen G / 2013 / Sevoflurane induces endoplasmic reticulum stress mediated apoptosis in hippocampal neurons of aging rats / PLoS ONE 8(2):e57870
Chen L / 2017 / Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats / Arch Gerontol Geriatr 73:29~36
Del Rosario A / 2012 / Effects of a high-fat diet and bamboo extract supplement on anxiety-and depression-like neurobehaviours in mice / Br J Nutr 108(7):1143~1149
Feng X / 2017 / Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice / JCI Insight 2(7):e91229
Chen G / 2013 / Sevoflurane induces endoplasmic reticulum stress mediated apoptosis in hippocampal neurons of aging rats / PLoS ONE 8(2):e57870
Chen L / 2017 / Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats / Arch Gerontol Geriatr 73:29~36
Del Rosario A / 2012 / Effects of a high-fat diet and bamboo extract supplement on anxiety-and depression-like neurobehaviours in mice / Br J Nutr 108(7):1143~1149
Feng X / 2017 / Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice / JCI Insight 2(7):e91229
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