지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 702 - 710 (9page)
이용수
초록· 키워드
오류제보하기
Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson’s disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters the brain, exerts neuroprotective effect, and inhibits NFκB activation. To further assess the utility of KMS99220 as a potential therapeutic agent for PD, we tested whether KMS99220 exerts an anti-inflammatory effect in vivo and examined the molecular mechanism mediating this phenomenon. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, oral administration of KMS99220 attenuated microglial activation and decreased the levels of inducible nitric oxide synthase and interleukin 1 beta (IL-1b)in the nigrostriatal system. In lipopolysaccharide (LPS)-challenged BV-2 microglial cells, KMS99220 suppressed the production and expression of IL-1b. In the activated microglia, KMS99220 reduced the phosphorylation of IκB kinase, c-Jun N-terminal kinase, and p38 MAP kinase; this effect was mediated by heme oxygenase-1 (HO-1), as both gene silencing and pharmacological inhibition of HO-1 abolished the effect of KMS99220. KMS99220 induced nuclear translocation of the transcription factor Nrf2 and expression of the Nrf2 target genes including HO-1. Together with our earlier findings, our current results show that KMS99220 may be a potential therapeutic agent for neuroinflammation-related neurodegenerative diseases such as PD.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Ahmed, S. M. / 2017 / Nrf2signaling pathway : pivotal roles in inflammation / Biochim. Biophys. Acta Mol. Basis Dis 1863:585~597
Alam, J. / 1999 / Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene / J. Biol. Chem 274:26071~26078
Blasi, E. / 1990 / Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus / J. Neuroimmunol 27:229~237
Bukhari, S. N. / 2013 / Anti-inflammatory trends of 1, 3-diphenyl-2-propen-1-one derivatives / Mini Rev. Med. Chem 13:87~94
Caivano, M. / 2000 / Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages / J. Immunol 164:3018~3025
Alam, J. / 1999 / Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene / J. Biol. Chem 274:26071~26078
Blasi, E. / 1990 / Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus / J. Neuroimmunol 27:229~237
Bukhari, S. N. / 2013 / Anti-inflammatory trends of 1, 3-diphenyl-2-propen-1-one derivatives / Mini Rev. Med. Chem 13:87~94
Caivano, M. / 2000 / Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages / J. Immunol 164:3018~3025
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Spatial Analysis on Marine Atmosphere Boundary Layer Features of SAR Imagery Using Empirical Mode Decomposition
대한원격탐사학회지
2017 .08
-
Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells
극지연구소 초록집
2021 .08
-
1 km급 심부복합지구물리 모니터링시스템 구축과 활용
대한지질학회 학술대회
2019 .10
-
13km, 8km 고해상도의 KIM 중기 예측 성능 분석
한국기상학회 학술대회 논문집
2022 .10
-
A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects
Molecules and Cells
2022 .03
-
Differential Effects of Transforming Growth Factor-β on NKG2D Ligands Expression and NK Cell-mediated Immune Responses in Primary and Metastatic Colon Cancer
생명과학회지
2023 .02
-
Complete genome sequence of Lactiplantibacillus plantarum KM2 from low-temperature aging beef
미생물학회지
2021 .12
-
시간 흐름에 따른 1km 초고해상도 장기 예측 자료 생산 시스템 구축
한국기상학회 학술대회 논문집
2016 .10
-
Glacier Change in the Yigong Zangbo Basin, Tibetan Plateau, China
대한원격탐사학회지
2019 .01
-
Prognostic value of Nrf2/HO-1 expression and its correlation with occurrence in esophageal squamous cell carcinoma
Genes & Genomics
2023 .06
-
유전자 알고리즘을 이용한 뉴질랜드 Ngauruhoe 화산 하부의 수신함수 역산
지구물리와 물리탐사
2015 .01
-
레일리파 토모그래피를 사용한 동아시아의 3차원 SV파 속도구조
지구물리와 물리탐사
2017 .01
-
Fortified Antioxidative Potential by Chrysoeriol through the Regulation of the Nrf2/MAPK-mediated HO-1 Signaling Pathway in RAW 264.7 Cells
생명과학회지
2018 .01
-
A Formulated Korean Red Ginseng Extract Inhibited Nitric Oxide Production through Akt- and Mitogen Activated Protein Kinase-dependent Heme Oxygenase-1 Upregulation in Lipoteichoic Acid-stimulated Microglial Cells
생명과학회지
2019 .04
-
Gardenia jasminoides Exerts Anti-inflammatory Activity via Akt and p38-dependent Heme Oxygenase-1 Upregulation in Microglial Cells
생명과학회지
2017 .01
-
전기비행기 2천km 넘는 장거리 비행 성공
Popular Science
2022 .06
-
2017년 1월 20일 영동 뇌설 사례에 대한연직바람관측장비와 라디오미터 관측 자료의 분석
대한원격탐사학회지
2018 .01
-
RAW 264.7 대식세포에서 바위수염 메탄올 추출물에 의한 lipopolysaccharide 유도 염증성 및 산화적 스트레스의 억제
한국해양바이오학회지
2024 .12
-
울트라 마라톤(100 km)에서 삼투압 농도와 전해질 대사의 생화학적 요인 변화에 대한 안전성 평가
대한임상검사과학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0