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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 569 - 578 (10page)
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초록· 키워드
오류제보하기
Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis. Recent improvements to analytical methods for genomics and metabolomics allow us to investigate these channels in both mutant animals and humans. In this review, we discuss three aspects of TRP channels, which are their role in metabolism, their functional characteristics, and their role in metabolic syndrome. First, we introduce each TRP channel superfamily and their particular roles in metabolism. Second, we provide evidence for which metabolites TRP channels affect, such as lipids or glucose. Third, we discuss correlations between TRP channels and obesity, diabetes, and mucolipidosis. The cellular metabolism of TRP channels gives us possible therapeutic approaches for an effective prophylaxis of metabolic syndromes.
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등록된 정보가 없습니다.
참고문헌 (107)
참고문헌 신청
Ahn, J. / 2014 / Allyl isothiocyanate ameliorates insulin resistance through the regulation of mitochondrial function / J. Nutr. Biochem 25:1026~1034
Baboota, R. K. / 2014 / Capsaicin induces"brite"phenotype in differentiating 3T3-L1 preadipocytes / PLoS One 9:e103093
Bang, S. / 2010 / Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3 / J. Biol. Chem 285:19362~19371
Bang, S. / 2011 / Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3and TRPA1 ion channels / Pain 152:1156~1164
Bang, S. / 2012 / Nociceptive and pro‐inflammatory effects of dimethylallyl pyrophosphate via TRPV4activation / Br. J. Pharmacol 166:1433~1443
Baboota, R. K. / 2014 / Capsaicin induces"brite"phenotype in differentiating 3T3-L1 preadipocytes / PLoS One 9:e103093
Bang, S. / 2010 / Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3 / J. Biol. Chem 285:19362~19371
Bang, S. / 2011 / Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3and TRPA1 ion channels / Pain 152:1156~1164
Bang, S. / 2012 / Nociceptive and pro‐inflammatory effects of dimethylallyl pyrophosphate via TRPV4activation / Br. J. Pharmacol 166:1433~1443
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