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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 15 - 21 (7page)
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초록· 키워드
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Background: Ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. E. cava polyphenols (ECPs) are known to increase fibroblast survival. The human dermal papilla cell (hDPC) has the properties of mesenchymal-origin fibroblasts.
Objective: This study aims to investigate the effect of ECPs on human hair growth promotion in vitro and ex vivo. Methods: MTT assays were conducted to examine the effect of ECPs on hDPC proliferation. Hair growth was measured using ex-vivo hair follicle cultures. Real-time polymerase chain reaction was performed to evaluate the mRNA expression of various growth factors in ECP-treated hDPCs. Results: Treatment with 10 μg/ml purified polyphenols from E. cava (PPE) enhanced the proliferation of hDPCs 30.3% more than in the negative control (p＜0.001). Furthermore, 0.1 μg/ml PPE extended the human hair shaft 30.8% longer than the negative control over 9 days (p＜0.05). Insulin-like growth factor- 1 (IGF-1) mRNA expression increased 3.2-fold in hDPCs following treatment with 6 μg/ml PPE (p＜0.05). Vascular endothelial growth factor (VEGF) mRNA expression was also increased 2.0-fold by 3 μg/ml PPE (p＜0.05). Treatment with 10 μg/ml PPE reduced oxidative stress in hDPCs (p＜0.05). Conclusion: These results suggest that PPE could enhance human hair growth. This can be explained by hDPC proliferation coupled with increases in growth factors such as IGF-1 and VEGF. Reducing oxidative stress is also thought to help increase hDPCs. These favorable results suggest that PPE is a promising therapeutic candidate for hair loss.
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참고문헌 (26)
참고문헌 신청
Wijesekara I. / 2010 / Phlorotannins from Ecklonia cava(Phaeophyceae) : biological activities and potential health benefits / Biofactors 36:408~414
Kang KA. / 2005 / Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells / FEBS Lett 579:6295~6304
Jung HA. / 2014 / Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes / J Pharm Pharmacol 66:1180~1188
Thomas NV. / 2013 / Beneficial effects of marine algal compounds in cosmeceuticals / Mar Drugs 11:146~164
Inui S. / 2003 / Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia / J Investig Dermatol Symp Proc 8:69~71
Kang KA. / 2005 / Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells / FEBS Lett 579:6295~6304
Jung HA. / 2014 / Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes / J Pharm Pharmacol 66:1180~1188
Thomas NV. / 2013 / Beneficial effects of marine algal compounds in cosmeceuticals / Mar Drugs 11:146~164
Inui S. / 2003 / Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia / J Investig Dermatol Symp Proc 8:69~71
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