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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 876 - 882 (7page)
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The antioxidant and anti-inflammatory effects of Corni fructus extracts (CEF, EtOAc extraction; CBF, buthanol extraction; CWF, water extraction) were investigated. The total phenolics of CEF (173.3 mg TAE/g) were significantly higher than those of CWF (26.7 mg TAE/g) and CBF (94.8 mg TAE/g). DPPH and ABTS free radical scavenging activity of CEF (DPPH: RH50; 25.1 μg/mL, ABTS: RC50; 36.1 μg/mL) showed even higher than that of BHA and α-tocopherol used as positive control. All three Corni fructus extracts in the concentration of 1~100 μg/mL were effective inhibitors of NO and prostaglandin E2 (PGE2). NO production was inhibited 71.3~92.2% by CEF, 76.8~85.5% by CBF and 74.4~96.9% by CWF, respectively. CEF, CBF and CWF (1~100 μg/mL) inhibited also pro-inflammatory cytokines like TNF-α, IL-1β and IL-6 very effectively. TNF-α was inhibited up to 51.2% by CWF and IL-1β was inhibited up to 67.1% by CEF. IL-6 was best inhibited by CEF up to 58.9%. This study suggested the potential of Corni fructus for use as an excellent antioxidant substance and inflammatory inhibiting mediators. Therefore CEF, CBF and CWF Corni fructus extracts may be used for therapeutic approach to various inflammatory diseases.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Tepe B / 2007 / Screening of the antioxidative properties and total phenolic contents of three endemic Tanacetum subspecies from Turkish flora / Bioresource Technol 98 : 3076 ~ 3079
[학술지(정기간행물)] - 김예진 / 2011 / Hot Water Leaves Extracts of Zizyphus jujube Exert Antioxidative Effects in Vitro and Cytotoxicity in Human Cancer Cell Lines / Horticulture, Environment, and Biotechnology 52 (6) : 635 ~ 640
[학술지(정기간행물)] - Albina JE / 1995 / Nitric oxide in inflammation and immunity / New Horiz 3 : 46 ~ 64
[학술지(정기간행물)] - Lee SJ / 2008 / Phytoglycoprotein inhibits interleukin-1β and interleukin-6 via p38 mitogen activated protein kinase in lipopolysaccharide stimulated RAW 264. 7 cells / Naunyn-Schmiedeberg’s Arch Pharmacol 377 : 45 ~ 54
[학술지(정기간행물)] - Higuchi M / 1990 / Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-argininge-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages / J Immunol 144 : 1425 ~ 1431
[학술지(정기간행물)] - 김예진 / 2011 / Hot Water Leaves Extracts of Zizyphus jujube Exert Antioxidative Effects in Vitro and Cytotoxicity in Human Cancer Cell Lines / Horticulture, Environment, and Biotechnology 52 (6) : 635 ~ 640
[학술지(정기간행물)] - Albina JE / 1995 / Nitric oxide in inflammation and immunity / New Horiz 3 : 46 ~ 64
[학술지(정기간행물)] - Lee SJ / 2008 / Phytoglycoprotein inhibits interleukin-1β and interleukin-6 via p38 mitogen activated protein kinase in lipopolysaccharide stimulated RAW 264. 7 cells / Naunyn-Schmiedeberg’s Arch Pharmacol 377 : 45 ~ 54
[학술지(정기간행물)] - Higuchi M / 1990 / Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-argininge-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages / J Immunol 144 : 1425 ~ 1431
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UCI(KEPA) : I410-ECN-0101-2018-059-003061421