Prognostic factors after curative resection hepatocellular carcinoma and the surgeon's role

Dong Do You; Dong Goo Kim; Chang Ho Seo; Ho Joong Choi; Young Kyung Yoo; Yong Gyu Park

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자료유형: 학술저널

저자정보: Dong Do You (The Catholic University of Korea) Dong Goo Kim (The Catholic University of Korea) Chang Ho Seo (The Catholic University of Korea) Ho Joong Choi (The Catholic University of Korea) Young Kyung Yoo (The Catholic University of Korea) Yong Gyu Park (The Catholic University of Korea)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.93 No.5

발행연도: 2017.11

수록면: 252 - 259 (8page)

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Purpose: Patient, surgical, and tumor factors affect the outcome after surgical resection for hepatocellular carcinoma (HCC). The surgical factors are only modifiable by the surgeon. We reviewed our experience with curative resection for HCC in terms of surgical factors.
Methods: After analyses of the prospectively collected clinical data of 256 consecutive patients undergoing surgical resection for HCC, prognostic factors for disease-free survival (DFS) and overall survival (OS) were identified; all patients were stratified by tumor diameters > or <5 cm and their outcomes were compared.
Results: Multivariate analyses showed that microvascular invasion, estimated blood loss, blood transfusion, and the number of tumors were independent adverse prognostic factors for DFS, whereas microvascular invasion, serum alpha fetoprotein, and tumor diameter were independent adverse prognostic factors for OS. Blood transfusion had borderline significance (P = 0.076). After stratification by tumor diameter, blood transfusion was only associated with poor DFS and OS in patients with tumor diameters > 5 cm.
Conclusion: Tumor recurrence after liver resection for HCC depends on tumor status, bleeding, and transfusions, which subsequently lead to poor patient survival. Surgeons can help improve the prognosis of patients by minimizing blood loss and transfusion, particularly in patients with larger tumors.

#Hepatocellular carcinomas #Surgeons #Liver cirrhosis #Prognosis #Hepatectomy

참고문헌 (30)

참고문헌 신청

[학술지(정기간행물)] - El-Serag HB. / 2011 / Hepatocellular carcinoma / N Engl J Med 365 : 1118 ~ 1127

[학술지(정기간행물)] - European Association For The Study Of The Liver / 2012 / EASL-EORTC clinical practice guidelines:management of hepatocellular carcinoma / J Hepatol 56 : 908 ~ 943

[학술지(정기간행물)] - Korean Liver Cancer Study Group / 2015 / 2014 Korean Liver Cancer Study Group-National Cancer Center Korea Practice Guideline for the Management of Hepatocellular Carcinoma / Korean Journal of Radiology 16 (3) : 465 ~ 522

[학술지(정기간행물)] - Fan ST / 2011 / Continuous improvement of survival outcomes of resection of hepatocellular carcinoma : a 20-year experience / Ann Surg 253 : 745 ~ 758

[학술지(정기간행물)] - Han DH / 2014 / Lesson from 610 liver resections of hepatocellular carcinoma in a single center over 10 years / World J Surg Oncol 12 : 192 ~

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